Linker Information
General Information of This Linker
| Linker ID |
LIN00024
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| Linker Name |
3-(1H-1,2,3-Triazol-4-yl)propanoic acid
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| Linker Type |
Enzyme-sensitive linkers
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| Structure |
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| Formula |
C5H7N3O2
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| #Ro5 Violations (Lipinski): 0 | Molecular Weight (mw) | 141.13 | ||||
| Lipid-water partition coefficient (xlogp) | -0.6 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 2 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 4 | |||||
| Rotatable Bond Count (rotbonds) | 3 | |||||
| PubChem CID | ||||||
| Canonical smiles |
C1=NNN=C1CCC(=O)O
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| InChI |
InChI=1S/C5H7N3O2/c9-5(10)2-1-4-3-6-8-7-4/h3H,1-2H2,(H,9,10)(H,6,7,8)
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| InChIKey |
JYKLORHRQMBGDN-UHFFFAOYSA-N
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| IUPAC Name |
3-(2H-triazol-4-yl)propanoic acid
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Each Peptide-drug Conjugate Related to This Linker
Full Information of The Activity Data of The PDC(s) Related to This Linker
EETI-2.5Z-ester-gemcitabine [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
5.2 ± 3.6 nM
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| Evaluation Method | CCK-8 assay | ||||
| Description |
Cell proliferation was quantified 4 d after treatment with each compoundusing CCK-8 colorimetric assays and compared to the untreated control.
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| In Vitro Model | Glioblastoma | U-87MG cell | CVCL_0022 | ||
| Experiment 2 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
8.5 ± 3.3 nM
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| Evaluation Method | CCK-8 assay | ||||
| Description |
Cell proliferation was quantified 4 d after treatment with each compoundusing CCK-8 colorimetric assays and compared to the untreated control.
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| In Vitro Model | Glioblastoma | U-87MG cell | CVCL_0022 | ||
References