Linker Information
General Information of This Linker
| Linker ID |
LIN00049
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| Linker Name |
Antitriazole
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| Linker Type |
Enzyme-sensitive linkers
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| Structure |
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| Formula |
C12H19N3O4
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| #Ro5 Violations (Lipinski): 0 | Molecular Weight (mw) | 269.301 | ||||
| Lipid-water partition coefficient (xlogp) | 1.3304 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 2 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 5 | |||||
| Rotatable Bond Count (rotbonds) | 10 | |||||
| Canonical smiles |
O=C(O)CCCCCn1cc(CCCC(=O)O)nn1
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| InChI |
InChI=1S/C12H19N3O4/c16-11(17)6-2-1-3-8-15-9-10(13-14-15)5-4-7-12(18)19/h9H,1-8H2,(H,16,17)(H,18,19)
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| InChIKey |
RQFPTOPQPZQKHV-UHFFFAOYSA-N
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Each Peptide-drug Conjugate Related to This Linker
Full Information of The Activity Data of The PDC(s) Related to This Linker
(123B9)2L2PTX [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Number of Lung metastases nodules |
5
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| Administration Time | 2 weeks | ||||
| Administration Dosage | 24.5 mg/kg | ||||
| Description |
We observed the clear and significant (p < 0.0001) beneficial effects of the dimer drug on lung metastasis (Figure5A,B), with a reduction of the gross lung-metastasis count by more than 75% compared with those in the control and Abraxane groups.
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| In Vivo Model | BALB/c mice syngeneic breast-cancer metastasis model. | ||||
References