Linker Information
General Information of This Linker
| Linker ID |
LIN00058
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| Linker Name |
(3-(1H-1,2,3-triazol-4-yl)propyl)carbamic acid
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| Linker Type |
Enzyme-sensitive linkers
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| Structure |
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| Formula |
C6H10N4O2
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| #Ro5 Violations (Lipinski): 0 | Molecular Weight (mw) | 170.172 | ||||
| Lipid-water partition coefficient (xlogp) | 0.0049 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 3 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 3 | |||||
| Rotatable Bond Count (rotbonds) | 4 | |||||
| Canonical smiles |
O=C(O)NCCCc1c[nH]nn1
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| InChI |
InChI=1S/C6H10N4O2/c11-6(12)7-3-1-2-5-4-8-10-9-5/h4,7H,1-3H2,(H,11,12)(H,8,9,10)
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| InChIKey |
ATGRUMHMIRMACN-UHFFFAOYSA-N
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Each Peptide-drug Conjugate Related to This Linker
Full Information of The Activity Data of The PDC(s) Related to This Linker
EETI-2.5Z-carbamate -gemcitabine [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
3.3 ± 0.2 nM
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| Evaluation Method | CCK-8 assay | ||||
| Description |
Cell proliferation was quantified 4 d after treatment with each compoundusing CCK-8 colorimetric assays and compared to the untreated control.
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| In Vitro Model | Glioblastoma | U-87MG cell | CVCL_0022 | ||
| Experiment 2 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Evaluation Method | CCK-8 assay | ||||
| Description |
Cell proliferation was quantified 4 d after treatment with each compoundusing CCK-8 colorimetric assays and compared to the untreated control.
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| In Vitro Model | Glioblastoma | U-87MG cell | CVCL_0022 | ||
References