Linker Information
General Information of This Linker
| Linker ID |
LIN00072
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| Linker Name |
PSA-cleavable linker (SSKYQSL)
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| Linker Type |
PSA-concentration-sensitive linkers
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| Structure |
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| Formula |
C35H57N9O13
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight (mw) | 811.891 | ||||
| Lipid-water partition coefficient (xlogp) | -5.3271 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 14 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 14 | |||||
| Rotatable Bond Count (rotbonds) | 33 | |||||
| Canonical smiles |
[H]NCCCCC(NC(=O)C(CO[H])NC(=O)C(CO[H])N[H])C(=O)NC(Cc1ccc(O[H])cc1)C(=O)NC(CCC(=O)N[H])C(=O)NC(CO[H])C(=O)NC(CC(C)C)C(=O)O
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| InChI |
InChI=1S/C35H57N9O13/c1-18(2)13-25(35(56)57)42-34(55)27(17-47)44-31(52)23(10-11-28(38)49)40-32(53)24(14-19-6-8-20(48)9-7-19)41-30(51)22(5-3-4-12-36)39-33(54)26(16-46)43-29(50)21(37)15-45/h6-9,18,21-27,45-48H,3-5,10-17,36-37H2,1-2H3,(H2,38,49)(H,39,54)(H,40,53)(H,41,51)(H,42,55)(H,43,50)(H,44,52)(H,56,57)/t21-,22-,23-,24-,25-,26-,27-/m0/s1
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| InChIKey |
QYRGYACIXYJGIR-DUJSLOSMSA-N
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Each Peptide-drug Conjugate Related to This Linker
Full Information of The Activity Data of The PDC(s) Related to This Linker
KYL-TGX [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Prostate cancer | ||||
| Efficacy Data | Inhinition rate |
14.93 µM
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| Administration Time | 72 h | ||||
| In Vitro Model | Prostate carcinoma | LNCaP C4-2 cell | CVCL_4782 | ||
| Half life period | 4 h | ||||
References