Peptide Information
General Information of This Peptide
| Peptide ID |
PEP00132
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| Peptide Name |
R9
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| Structure |
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| Sequence |
RRRRRRRRR
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| Peptide Type |
Linear
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| PDC Transmembrane Types | Cell-penetrating peptides (CPPs) | |||||
| Formula |
C54H110N36O10
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| Isosmiles |
[H]N/C(N)=N/CCC[C@H](NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@H](CCC/N=C(\N)N[H])NC(=O)[C@@H](N)CCC/N=C(\N)N[H])C(=O)O
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| InChI |
InChI=1S/C54H110N36O10/c55-28(10-1-19-74-46(56)57)37(91)83-29(11-2-20-75-47(58)59)38(92)84-30(12-3-21-76-48(60)61)39(93)85-31(13-4-22-77-49(62)63)40(94)86-32(14-5-23-78-50(64)65)41(95)87-33(15-6-24-79-51(66)67)42(96)88-34(16-7-25-80-52(68)69)43(97)89-35(17-8-26-81-53(70)71)44(98)90-36(45(99)100)18-9-27-82-54(72)73/h28-36H,1-27,55H2,(H,83,91)(H,84,92)(H,85,93)(H,86,94)(H,87,95)(H,88,96)(H,89,97)(H,90,98)(H,99,100)(H4,56,57,74)(H4,58,59,75)(H4,60,61,76)(H4,62,63,77)(H4,64,65,78)(H4,66,67,79)(H4,68,69,80)(H4,70,71,81)(H4,72,73,82)/t28-,29-,30-,31-,32-,33-,34-,35-,36-/m0/s1
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| InChIKey |
XUNKPNYCNUKOAU-VXJRNSOOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1423.716
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Polar area
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875.72
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Complexity
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1422.920564
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xlogp Value
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-13.2409
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Heavy Count
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100
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Rot Bonds
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53
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Hbond acc
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19
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Hbond Donor
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28
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Each Peptide-drug Conjugate Related to This Peptide
Full Information of The Activity Data of The PDC(s) Related to This Peptide
Cq-C4-R9 [Investigative]
Obtained from the Model Organism Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Malaria | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 10 µM | |||
| MOA of PDC |
The significant increase in the hemolytic activity of TP10 upon conjugation to the 4-aminoquinoline suggests that drug cargo prevents an otherwise active CPP carrier from exerting the desired cell penetrating/antiplasmodial action safely, as it produces conjugates that exert membranolytic activity.
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| Description |
Only three of the Cq-C4-CPP conjugates, namely, 5a, 5b, and 5g, displayed IC50 values below 10 μM, with TP10- and Transportan-derived conjugates 5a (IC50 = 1.52 μM) and 5b (IC50 = 5.20 μM) being the most active.
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| In Vivo Model | Plasmodium falciparum W2. | ||||
References