Peptide Information
General Information of This Peptide
| Peptide ID |
PEP00144
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| Peptide Name |
DPT-sh1
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| Structure |
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| Sequence |
VKKKKIKREIKI
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| Peptide Type |
Linear
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| PDC Transmembrane Types | Cell-penetrating peptides (CPPs) | |||||
| Formula |
C70H135N21O15
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| Isosmiles |
[H]NCCCC[C@H](NC(=O)[C@H](CCCCN[H])NC(=O)[C@H](CCCCN[H])NC(=O)[C@@H](N[H])C(C)C)C(=O)N[C@@H](CCCCN[H])C(=O)N[C@]([H])(C(=O)N[C@@H](CCCCN[H])C(=O)N[C@@H](CCC/N=C(\N)N[H])C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@]([H])(C(=O)N[C@@H](CCCCN[H])C(=O)N[C@]([H])(C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC
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| InChI |
InChI=1S/C70H135N21O15/c1-9-42(6)55(89-63(99)49(29-16-22-38-75)83-59(95)46(26-13-19-35-72)81-58(94)45(25-12-18-34-71)82-60(96)47(27-14-20-36-73)86-66(102)54(77)41(4)5)67(103)87-48(28-15-21-37-74)61(97)84-51(31-24-40-80-70(78)79)62(98)85-52(32-33-53(92)93)65(101)90-56(43(7)10-2)68(104)88-50(30-17-23-39-76)64(100)91-57(69(105)106)44(8)11-3/h41-52,54-57H,9-40,71-77H2,1-8H3,(H,81,94)(H,82,96)(H,83,95)(H,84,97)(H,85,98)(H,86,102)(H,87,103)(H,88,104)(H,89,99)(H,90,101)(H,91,100)(H,92,93)(H,105,106)(H4,78,79,80)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,54-,55-,56-,57-/m0/s1
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| InChIKey |
CYZOBFMMTBQOKB-SYYWVYDKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1510.982
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Polar area
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641.24
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Complexity
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1510.044653
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xlogp Value
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-2.7822
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Heavy Count
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106
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Rot Bonds
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68
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Hbond acc
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21
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Hbond Donor
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22
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Each Peptide-drug Conjugate Related to This Peptide
Full Information of The Activity Data of The PDC(s) Related to This Peptide
Cq-C4-DPT-sh1 [Investigative]
Obtained from the Model Organism Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Malaria | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 10 µM | |||
| MOA of PDC |
The significant increase in the hemolytic activity of TP10 upon conjugation to the 4-aminoquinoline suggests that drug cargo prevents an otherwise active CPP carrier from exerting the desired cell penetrating/antiplasmodial action safely, as it produces conjugates that exert membranolytic activity.
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| Description |
Only three of the Cq-C4-CPP conjugates, namely, 5a, 5b, and 5g, displayed IC50 values below 10 μM, with TP10- and Transportan-derived conjugates 5a (IC50 = 1.52 μM) and 5b (IC50 = 5.20 μM) being the most active.
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| In Vivo Model | Plasmodium falciparum W2. | ||||
References