Target Information

General Information of This Target
Target ID
TAR10001
Target Name
Alpha-2A adrenergic receptor (ADRA2A)
Gene Name
ADRA2A
Gene ID
150
Synonym
ADRA2R, ADRAR; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor
Sequence
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS
FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR
RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP
RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP
AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR
TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV

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3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Family
the G-protein coupled receptor 1 family
Function
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p- octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

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Uniprot Entry
ADA2A_HUMAN
HGNC ID
HGNC:281
KEGG ID
hsa:150
Full List of The PDC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
PDC Info PDC Name Peptide Receptor Drug Linker
 PDC Info 
HR97-brimonidine
HR97
Cell membrane
Brimonidine
Mc-Val-Cit-PAB-OH