Target Information
General Information of This Target
| Target ID |
TAR10003
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| Target Name |
Hematopoietic prostaglandin D synthase (HPGDS)
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| Gene Name |
HPGDS
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| Gene ID | ||||||
| Synonym |
GSTS, PGDS, PTGDS2; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase
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| Sequence |
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK VQAIPAVANWIKRRPQTKL
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| 3D Structure | ||||||
| Family |
the GST superfamily, Sigma family
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| Function |
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
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Full List of The PDC Related to This Target
Investigative
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
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PP-P5
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P5
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Undisclosed
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Protoporphyrin IX
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Amide bond
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PP-P6
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P6
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Undisclosed
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Protoporphyrin IX
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Amide bond
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PP-P1
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P1
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Undisclosed
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Protoporphyrin IX
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Amide bond
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PP-P2
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P2
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Undisclosed
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Protoporphyrin IX
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Amide bond
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XHWSYKLRPG - Protoporphyrin IX conjugate
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Protoporphyrin IX
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Undisclosed
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XFWSYKLRPG - Protoporphyrin IX conjugate
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XFWSYKLRPG
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Undisclosed
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Protoporphyrin IX
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Undisclosed
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SV40 nuclear transport signal peptide analog - Protoporphyrin IX conjugate
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SV40 nuclear transport signal peptide analog
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Undisclosed
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Protoporphyrin IX
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Undisclosed
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Tetrapeptide 50 - Protoporphyrin IX conjugate
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Tetrapeptide 50
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Undisclosed
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Protoporphyrin IX
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Undisclosed
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