Target Information

General Information of This Target
Target ID
TAR10013
Target Name
Biliverdin reductase A (BLVRA)
Gene Name
BLVRA
Gene ID
644
Synonym
Biliverdin-IX alpha-reductase
Sequence
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

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3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Family
the Gfo/Idh/MocA family
Function
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems.

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Uniprot Entry
BIEA_HUMAN
HGNC ID
HGNC:1062
KEGG ID
hsa:644
Full List of The PDC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
PDC Info PDC Name Peptide Receptor Drug Linker
 PDC Info 
RR-BA
RR
Cathepsin B (CTSB)
Ursodeoxycholic acid
Amide bond