Linker Information

General Information of This Linker
Linker ID
LIN00025
Linker Name
NODAGA
Structure
Formula
C10H16N2O7
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 276.24
Lipid-water partition coefficient (xlogp) -4.3
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 8
Rotatable Bond Count (rotbonds) 9
PubChem CID
558343
Canonical smiles
C(CC(=O)NC(CCC(=O)O)C(=O)O)C(C(=O)O)N
InChI
InChI=1S/C10H16N2O7/c11-5(9(16)17)1-3-7(13)12-6(10(18)19)2-4-8(14)15/h5-6H,1-4,11H2,(H,12,13)(H,14,15)(H,16,17)(H,18,19)
InChIKey
OWQDWQKWSLFFFR-UHFFFAOYSA-N
IUPAC Name
2-[(4-amino-4-carboxybutanoyl)amino]pentanedioic acid
Each Peptide-drug Conjugate Related to This Linker
Full Information of The Activity Data of The PDC(s) Related to This Linker
68Ga-NODAGA-E[c(RGDyK)]2 [Phase 3]
 PDC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Data of This PDC [1]
Indication Glioblastoma
Efficacy Data Radiochemical purity
89%-99%
In Vivo Model Nude mice bearing either human glioblastoma (U87MG)/human neuroendocrine (H727) xenograft tumors.
64Cu-NODAGA-E[c(RGDyK)]2 [Investigative]
 PDC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Data of This PDC [1]
Indication Glioblastoma
Efficacy Data Radiochemical purity
92%-99%
In Vivo Model Nude mice bearing either human glioblastoma (U87MG)/human neuroendocrine (H727) xenograft tumors.
References
Ref 1 Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and (64)Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors. Nucl Med Biol. 2014 Mar;41(3):259-67. doi: 10.1016/j.nucmedbio.2013.12.003. Epub 2013 Dec 12.