Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00041
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| PDC Name |
68Ga-NODAGA-E[c(RGDyK)]2
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| PDC Status |
Phase 3
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| Indication |
In total 1 Indication(s)
Glioblastoma
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| Structure |
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| Peptide Name |
c(RGDyK)
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Peptide Info | ||||
| Receptor Name |
Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
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Receptor Info | ||||
| Drug Name |
Gallium-68
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Drug Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
NODAGA
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Linker Info | ||||
| Peptide Modified Type |
Amino acid modifications; Cyclization modification
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| Modified Segment |
Use D-amino acids instead of L-amino acids; Head-to-tail cyclization
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| Formula |
C74H107GaN22O25
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight | 1772.72698 | ||||
| Lipid-water partition coefficient (xlogp) | -12.72776 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 23 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 28 | |||||
| Rotatable Bond Count (rotbonds) | 40 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Radiochemical purity |
89%-99%
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| In Vivo Model | Nude mice bearing either human glioblastoma (U87MG)/human neuroendocrine (H727) xenograft tumors. | ||||
References