Receptor Information
General Information of This Receptor
| Receptor ID |
REC00013
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| Receptor Name |
Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
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| Gene Name |
ITGAV; ITGB3
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| Gene ID | ||||||
| Synonym |
Vitronectin receptor ; Vitronectin receptor subunit alpha; CD_antigen=CD51
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| Sequence |
MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSA
SSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKS HQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDAD GQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLAT RTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGE QMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTK LNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQI LEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVY PSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRR ALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAAD TTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVK AQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAG TQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSP DHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLY ILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIH TLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIE FPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGF FKRVRPPQEEQEREQLQPHENGEGNSET
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| Family |
the integrin alpha chain family
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| Function |
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1- dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling . ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling . ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 . Integrin alpha-V/beta-6 or alpha- V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF- beta-1 activation . ITGAV:ITGB3 acts as a receptor for CD40LG . ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP . (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1; (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
c(RGDfK)
| PDC Info | PDC Name | Drug | Target | Linker |
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99mTc-3PRGD2
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Technetium-99m
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Human Deoxyribonucleic acid (hDNA)
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PEG2
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BGC-0222
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Irinotecan
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DNA topoisomerase 1 (TOP1)
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PEG114
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Conjugates 1a
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Chlorambucil
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DNA topoisomerase 2-alpha (TOP2A)
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Amide bond
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Conjugates 1c
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Chlorambucil
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DNA topoisomerase 2-alpha (TOP2A)
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Amide; Ester
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Conjugates 8a
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Chlorambucil
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DNA topoisomerase 2-alpha (TOP2A)
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Amide bond
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Conjugates 8b
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Chlorambucil
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DNA topoisomerase 2-alpha (TOP2A)
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Ester bond
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Conjugates 1b
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Carbamic acid
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Conjugates 8c
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Carbamic acid
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cRGD-SMCC-DM1
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Mertansine DM1
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Microtubule (MT)
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Sulfo-SMCC
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cRGD-SS-DM1
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Mertansine DM1
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Microtubule (MT)
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Disulfide bond
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Conjugates 1d
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Chlorambucils; Camptothecins
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DNA topoisomerase 1 (TOP1); Human Deoxyribonucleic acid (hDNA)
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Amide; Carbamate
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c(RGDfK) - 2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide conjugate
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2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide
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Undisclosed
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Undisclosed
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c(RGDfK) - Ureidopyrimidinone conjugate 1
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Ureidopyrimidinone
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Undisclosed
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Undisclosed
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c(RGDfK) - Ureidopyrimidinone conjugate 2
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Ureidopyrimidinone
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Undisclosed
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Undisclosed
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c(RGDfK) - Ureidopyrimidinone conjugate 3
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Ureidopyrimidinone
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Undisclosed
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PEG
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c(RGDfK) - 9-Fluorenylmethyl chloroformate conjugate
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9-Fluorenylmethyl chloroformate
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Undisclosed
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PEG
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c(RGDfK) - Diethyl squarate conjugate 1
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Diethyl squarate
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Undisclosed
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PEG
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c(RGDfK) - Diethyl squarate conjugate 2
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Diethyl squarate
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Undisclosed
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PEG
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RGDFK - 3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonic acid conjugate
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3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonic acid
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Undisclosed
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Undisclosed
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RGDFK - O-β-D-Galactopyranosyl-(13)-O-β-D-galactopyranosyl-(14)-β-D-glucopyranose conjugate
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O-β-D-Galactopyranosyl-(1-3)-O-β-D-galactopyranosyl-(1-4)-β-D-glucopyranose
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Undisclosed
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PEG
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GPU-201
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Ortho carborane
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Undisclosed
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Butyric acid
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c(RGDyK)
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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68Ga-NODAGA-E[c(RGDyK)]2
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Gallium-68
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Human Deoxyribonucleic acid (hDNA)
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NODAGA
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Geo75
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JH-VII-139-1
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SRSF protein kinase 1 (SRPK1)
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(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-nitrophenyl) dicarbonate
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Geo77
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JH-VII-139-1
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SRSF protein kinase 1 (SRPK1)
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Glutaric acid
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Geo85
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JH-VII-139-1
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SRSF protein kinase 1 (SRPK1)
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2-[2-[2-(Carboxyamino)ethoxy]ethoxy]ethylcarbamic acid
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64Cu-NODAGA-E[c(RGDyK)]2
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Copper-64
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Human Deoxyribonucleic acid (hDNA)
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NODAGA
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ALOS4
| PDC Info | PDC Name | Drug | Target | Linker |
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ALOS4-CPT
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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GABA
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c(RPQfK)
| PDC Info | PDC Name | Drug | Target | Linker |
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cRPQ-SMCC-DM1
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Mertansine DM1
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Microtubule (MT)
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Sulfo-SMCC
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cRPQ-SS-DM1
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Mertansine DM1
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Microtubule (MT)
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Disulfide bond
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C(StBu)GASGGKK
| PDC Info | PDC Name | Drug | Target | Linker |
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Oxali-PtY1
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Platinum(IV)
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Undisclosed
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(2-(3-mercapto-2,5-dioxopyrrolidin-1-yl)ethyl)carbamic acid
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GFLG
| PDC Info | PDC Name | Drug | Target | Linker |
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RGD-GFLG-DOX
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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GFLG
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GFLG - Doxorubicin conjugate
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Undisclosed
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GFLG - Doxorubicine conjugate
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Undisclosed
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GFLG - 3-Maleimidopropionic acid conjugate
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3-Maleimidopropionic acid
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Undisclosed
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Undisclosed
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RGDKLAK
| PDC Info | PDC Name | Drug | Target | Linker |
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CPP-SA-PTX
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Paclitaxel
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Microtubule (MT)
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Succinic Acid
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