Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00073
|
|||||
|---|---|---|---|---|---|---|
| PDC Name |
Conjugates 1a
|
|||||
| PDC Status |
Investigative
|
|||||
| Structure |
|
|||||
| Peptide Name |
c(RGDfK)
|
Peptide Info | ||||
| Receptor Name |
Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
|
Receptor Info | ||||
| Drug Name |
Chlorambucil
|
Drug Info | ||||
| Therapeutic Target |
DNA topoisomerase 2-alpha (TOP2A)
|
Target Info | ||||
| Linker Name |
Amide bond
|
Linker Info | ||||
| Peptide Modified Type |
Amino acid modifications; Cyclization modification
|
|||||
| Modified Segment |
Use D-amino acids instead of L-amino acids; Head-to-tail cyclization
|
|||||
| Formula |
C61H87Cl4N13O10
|
|||||
| #Ro5 Violations (Lipinski): 4 | Molecular Weight | 1304.26 | ||||
| Lipid-water partition coefficient (xlogp) | 3.70767 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 12 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 12 | |||||
| Rotatable Bond Count (rotbonds) | 38 | |||||