Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_02101
|
|||||
|---|---|---|---|---|---|---|
| PDC Name |
SN38(10)-5-CRGDK
|
|||||
| PDC Status |
Investigative
|
|||||
| Structure |
|
|||||
| Peptide Name |
CRGDK
|
Peptide Info | ||||
| Receptor Name |
Neuropilin-1 (NRP1)
|
Receptor Info | ||||
| Drug Name |
7-Ethyl-10-hydroxycamptothecin
|
Drug Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
|
Target Info | ||||
| Linker Name |
5-(2-Disulfaneylethoxy)-5-oxopentanoic acid
|
Linker Info | ||||
| Formula |
C50H67N11O16S2
|
|||||
| #Ro5 Violations (Lipinski): 4 | Molecular Weight | 1142.281 | ||||
| Lipid-water partition coefficient (xlogp) | -0.7179 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 11 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 21 | |||||
| Rotatable Bond Count (rotbonds) | 34 | |||||