Target Information

General Information of This Target
Target ID
TAR10014
Target Name
Peroxisome proliferator-activated receptor alpha (PPARA)
Gene Name
PPARA
Gene ID
5465
Synonym
NR1C1, PPAR; Nuclear receptor subfamily 1 group C member 1
Sequence
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

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3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Family
the nuclear hormone receptor family
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

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Uniprot Entry
PPARA_HUMAN
HGNC ID
HGNC:9232
KEGG ID
hsa:5465
Full List of The PDC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
PDC Info PDC Name Peptide Receptor Drug Linker
 PDC Info 
Tesaglitazar-[F7, P34]-NPY
[K4(C-βA-),F7,L17,P34]-hNPY
Neuropeptide Y receptor type 1 (NPY1R)
Tesaglitazar
GFLG