Target Information
General Information of This Target
| Target ID |
TAR10032
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| Target Name |
Prostaglandin G/H synthase 1 (COX-1)
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| Gene Name |
PTGS1
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| Gene ID | ||||||
| Sequence |
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
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| 3D Structure | ||||||
| Family |
the prostaglandin G/H synthase family
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| Function |
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
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Full List of The PDC Related to This Target
Investigative
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
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Dipeptide 34 - Naproxen conjugate 1
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Dipeptide 34
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Undisclosed
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Naproxen
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Undisclosed
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Dipeptide 34 - Naproxen conjugate 2
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Dipeptide 34
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Undisclosed
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Naproxen
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Undisclosed
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Dipeptide 34 - Naproxen conjugate 3
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Dipeptide 34
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Undisclosed
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Naproxen
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Undisclosed
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Glutamic acid oligopeptide 1 - Ibuprofen conjugate 3
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Glutamic acid oligopeptide 1
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Undisclosed
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Naproxen
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Undisclosed
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Glutamic acid oligopeptide 1 - Ibuprofen conjugate 4
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Glutamic acid oligopeptide 1
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Undisclosed
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Naproxen
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Undisclosed
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Glutamic acid oligopeptide 2 - Ibuprofen conjugate 3
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Glutamic acid oligopeptide 2
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Undisclosed
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Naproxen
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Undisclosed
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Glutamic acid oligopeptide 2 - Ibuprofen conjugate 4
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Glutamic acid oligopeptide 2
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Undisclosed
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Naproxen
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Undisclosed
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Glutamic acid oligopeptide 3 - Ibuprofen conjugate 3
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Glutamic acid oligopeptide 3
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Undisclosed
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Naproxen
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Undisclosed
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Glutamic acid oligopeptide 3 - Ibuprofen conjugate 4
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Glutamic acid oligopeptide 3
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Undisclosed
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Naproxen
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Undisclosed
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Tripeptide 68 - Naproxen conjugate 1
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Tripeptide 68
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Undisclosed
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Naproxen
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Undisclosed
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Tripeptide 68 - Naproxen conjugate 2
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Tripeptide 68
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Undisclosed
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Naproxen
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Undisclosed
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Tripeptide 68 - Naproxen conjugate 3
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Tripeptide 68
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Undisclosed
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Naproxen
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Undisclosed
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Tripeptide 68 - Naproxen conjugate 4
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Tripeptide 68
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Undisclosed
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Naproxen
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Undisclosed
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Linear arginineglycineaspartic acid (RGD) - Naproxen conjugate 3
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RGD
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Integrin
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Naproxen
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Amide bond
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Linear arginineglycineaspartic acid (RGD) - Naproxen conjugate 4
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RGD
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Integrin
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Naproxen
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Aminocaproic acid
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Linear asparagineglycinearginine (NGR) 1 - Naproxen conjugate 1
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NGR
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Aminopeptidase N (ANPEP)
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Naproxen
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Amide bond
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Linear asparagineglycinearginine (NGR) 1 - Naproxen conjugate 2
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NGR
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Aminopeptidase N (ANPEP)
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Naproxen
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Aminocaproic acid
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