Receptor Information

General Information of This Receptor
Receptor ID
REC00026
Receptor Name
fMet-Leu-Phe receptor (FPR1)
Gene Name
FPR1
Gene ID
2357
Synonym
N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Sequence
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVT
TISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIA
LDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNF
SPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPL
RVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPML
YVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK

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3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Family
the G-protein coupled receptor 1 family
Function
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors . Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release . This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system . Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release . Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis.

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Uniprot Entry
FPR1_HUMAN
HGNC ID
HGNC:3826
KEGG ID
hsa:2357
Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
PDC Info PDC Name Drug Target Linker
 PDC Info 
DOX-EMCH-fMLFC
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
N-ε-maleimidocaproic acid hydrazide