Receptor Information

General Information of This Receptor
Receptor ID
REC00032
Receptor Name
Somatostatin receptor type 2 (SSTR2)
Gene Name
SSTR2
Gene ID
6752
Synonym
SRIF-1
Sequence
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI

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3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Family
the G-protein coupled receptor 1 family
Function
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

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Uniprot Entry
SSR2_HUMAN
HGNC ID
HGNC:11331
KEGG ID
hsa:6752
Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
[Tyr3,Cys8] Octreotate amide
 Peptide Info 
PDC Info PDC Name Drug Target Linker
 PDC Info 
PEN-221
Mertansine DM1
Microtubule (MT)
Disulfide bond
Potent somatostatin analog (SSA)
 Peptide Info 
PDC Info PDC Name Drug Target Linker
 PDC Info 
JF-10-81
Camptothecin
DNA topoisomerase 1 (TOP1)
N-carboxy-N-(2-(methylamino)ethyl)glycine
 PDC Info 
JF-10-71
Camptothecin
DNA topoisomerase 1 (TOP1)
N-(2-aminoethyl)-N-carboxyglycine