Receptor Information
General Information of This Receptor
| Receptor ID |
REC00041
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| Receptor Name |
Melanocyte-stimulating hormone receptor (MC1R)
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| Gene Name |
MC1R
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| Gene ID | ||||||
| Synonym |
MSHR; Melanocortin receptor 1
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| Sequence |
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF HSQELRRTLKEVLTCSW
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| 3D Structure | ||||||
| Family |
the G-protein coupled receptor 1 family
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| Function |
Receptor for MSH (alpha, beta and gamma) and ACTH . The activity of this receptor is mediated by G proteins which activate adenylate cyclase . Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes .
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| Uniprot Entry | ||||||
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Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
Ac-NleEHfRWGK-NH2
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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Ac-NleEHfRWGK(Dau=Aoa)-NH2
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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Ac-SYSNleEHFRWGKPV-NH2
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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Ac-SYSNleEHFRWGK(Dau=Aoa)PV-NH2
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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Dau=Aoa-SYSNleEHFRWGK(Dau=Aoa)PV-NH2
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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Dau=Aoa-SYSNleEHFRWGKPV-NH2
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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