Receptor Information
General Information of This Receptor
| Receptor ID |
REC00063
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| Receptor Name |
DNA gyrase subunit B (gyrB)
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| Gene Name |
gyrB
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| Sequence |
MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
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| 3D Structure | ||||||
| Family |
the type II topoisomerase GyrB family
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| Function |
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. HAMAP- Rule:MF_01898.
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| Uniprot Entry | ||||||
Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
FRARXRARXRAR
| PDC Info | PDC Name | Drug | Target | Linker |
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FRARXRARXRAR - Nalidixic acid conjugate
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Nalidixic Acid
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Undisclosed
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Amide bond
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RXRX
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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RXRX - Nalidixic acid conjugate
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Nalidixic Acid
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Undisclosed
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Amide bond
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RXRXRX
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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RXRXRX - Nalidixic acid conjugate
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Nalidixic Acid
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Undisclosed
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Amide bond
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XRRR
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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XRRR - Nalidixic acid conjugate
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Nalidixic Acid
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Undisclosed
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Amide bond
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XRXRXRX
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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XRXRXRX - Nalidixic acid conjugate
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Nalidixic Acid
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Undisclosed
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Amide bond
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