Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00064
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| PDC Name |
ANG-TAT-PTX
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| PDC Status |
Investigative
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| Indication |
In total 1 Indication(s)
Central nervous system disease
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| Structure |
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| Peptide Name |
Angiopep-2/TAT
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Peptide Info | ||||
| Receptor Name |
Prolow-density lipoprotein receptor-related protein 1 (LRP1)
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Receptor Info | ||||
| Drug Name |
Paclitaxel
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Drug Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Ester bond
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Linker Info | ||||
| Formula |
C236H349N69O64S
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight | 5208.874 | ||||
| Lipid-water partition coefficient (xlogp) | -20.9193 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 68 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 76 | |||||
| Rotatable Bond Count (rotbonds) | 170 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Central nervous system disease | ||||
| Efficacy Data | Inhinition rate |
31.65 ± 3.28%
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| Administration Time | 24 h | ||||
| In Vitro Model | Glioblastoma | U87 cell | CVCL_3429 | ||
| Experiment 2 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Central nervous system disease | ||||
| Efficacy Data | Inhinition rate |
73.53 ± 6.45%
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| Administration Time | 48 h | ||||
| In Vitro Model | Glioblastoma | U87 cell | CVCL_3429 | ||
References