Target Information
General Information of This Target
| Target ID |
TAR10017
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| Target Name |
Microtubule (MT)
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| Function |
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules play an important role in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella. They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organelles, and intracellular macromolecular assemblies.
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Full List of The PDC Related to This Target
Phase 3
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
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TH1902
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TH19P01
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Sortilin (SORT1)
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Docetaxel
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Succinic Acid
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|
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ANG1005
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Angiopep-2
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Prolow-density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 2 (LRP1; LRP2)
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Paclitaxel
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Succinic Acid
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Phase 2/3
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
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BT8009
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Bicycle toxin conjugate precursor
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Nectin-4 (NECTIN4)
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Monomethyl auristatin E
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Val-Cit
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|
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CBP-1008
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SOR-C13
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Transient receptor potential cation channel subfamily V member 6 (TRPV6)
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Monomethyl auristatin E
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Mc-Val-Cit-PAB-OH
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Phase 2
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
|
PEN-221
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[Tyr3,Cys8] Octreotate amide
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Somatostatin receptor type 2 (SSTR2)
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Mertansine DM1
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Disulfide bond
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|
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BT1718
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BT1718 Bicycle peptide
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Matrix metalloproteinase-14 (MMP14)
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Maytansine
|
Disulfide bond
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Phase 1/2
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
|
BT5528
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BCY6099
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Ephrin type-A receptor 2 (EPHA2)
|
Monomethyl auristatin E
|
Val-Cit
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Phase 1
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
|
CBP-1018
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LDC10B
|
Glutamate carboxypeptidase 2 (FOLH1)
|
Monomethyl auristatin E
|
Mc-Val-Cit-PAB-OH
|
Preclinical
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
|
DTX-P7
|
Heptapeptide
|
Heat shock protein HSP 90-alpha (HSP90AA1)
|
Docetaxel
|
Succinic Acid
|
|
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SBI1301
|
SOR-C27
|
Transient receptor potential cation channel subfamily V member 6 (TRPV6)
|
Paclitaxel
|
Thioglycolic acid
|
Investigative
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
|
M-DM1
|
M
|
M2-like tumor-associated macrophages
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Mertansine DM1
|
N-succinimidyl-3-maleimidopropionate
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|
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mPEG-AAN-PTP-7-CDM-PTX
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CAAN-PTP-7
|
Cell membrane
|
Paclitaxel
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CDM
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|
|
1131-MMAE
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Peptide 1131
|
Kita-kyushu lung cancer antigen 1 (CT83)
|
Monomethyl auristatin E
|
Mc-Vc-PABC
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|
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PTX-SM-TAR
|
TAR
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Neuropilin-1 (NRP1)
|
Paclitaxel
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SA-MAL
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|
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MPD3
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DEVD
|
Caspase-3 (CASP3)
|
Docetaxel
|
(4-Aminophenyl)methyl hydrogen carbonate
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|
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CTCE-DTX
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CTCE
|
C-X-C chemokine receptor type 4 (CXCR4)
|
Docetaxel
|
Thiol group (SH) and maleimide
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|
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P-(A5G27)-PTX
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P-(A5G27)-FITC
|
CD44 antigen (CD44)
|
Paclitaxel
|
4-(2-(glycylglycyl)hydrazineylidene)pentanoic acid
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|
|
Doce-βA-thioether-CGFLG-C6-[KTVRTSADE]
|
KTVRTSADE
|
Fibronectin (FN1)
|
Docetaxel
|
A-thioether-CGFLG-C6
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|
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P-(A5G27scrm)-PTX
|
P-(A5G27scrm)-FITC
|
CD44 antigen (CD44)
|
Paclitaxel
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4-(2-(glycylglycyl)hydrazineylidene)pentanoic acid
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|
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SC-CTCE-DTX
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Scrambled -CTCE
|
Undisclosed
|
Docetaxel
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Thiol group (SH) and maleimide
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|
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ER-472
|
Chlorotoxin
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Neuropilin-1 (NRP1)
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Cryptophycin analog
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Dimethyl disulfide
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|
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[64Cu]PDC-1
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αvβ6-BP
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Integrin alpha-V; Integrin beta-6 (ITGAV; ITGB6)
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Monomethyl auristatin E
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Mc-PEG2-Val-Cit-PABC
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|
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LWJ-M30
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B6
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Transferrin receptor protein 1 (TFRC)
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Maytansine
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Disulfide bond
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|
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PVGLIG-paclitaxel
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Hexapeptide
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72 kDa type IV collagenase (MMP2)
|
Paclitaxel
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Ester bond
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|
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cRGD-SMCC-DM1
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c(RGDfK)
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Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
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Mertansine DM1
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Sulfo-SMCC
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cRGD-SS-DM1
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c(RGDfK)
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Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
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Mertansine DM1
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Disulfide bond
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CPP-SA-PTX
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RGDKLAK
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Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
|
Paclitaxel
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Succinic Acid
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cRPQ-SMCC-DM1
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c(RPQfK)
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Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
|
Mertansine DM1
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Sulfo-SMCC
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cRPQ-SS-DM1
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c(RPQfK)
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Integrin alpha-V; Integrin beta-3 (ITGAV; ITGB3)
|
Mertansine DM1
|
Disulfide bond
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ANG-TAT-PTX
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Angiopep-2/TAT
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Prolow-density lipoprotein receptor-related protein 1 (LRP1)
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Paclitaxel
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Ester bond
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M1-PTX
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M1
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Undisclosed
|
Paclitaxel
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Succinic Acid
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M1-RGD-PTX
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M1-RGD
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Undisclosed
|
Paclitaxel
|
Succinic Acid
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PDC-PTX1
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Cyclic peptide [W(WR)4K(βAla)]
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Undisclosed
|
Paclitaxel
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Glutaric acid
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|
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D-Cys6-LHRH vedotin
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LHRH
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Progonadoliberin-1 (GNRH1)
|
Monomethyl auristatin E
|
Maleimidocaproyl (MC) moiety-valine-citrulline (VC) dipeptide-para-aminobenzyloxycarbamoyl (PABC) spacer (MC-VC-PABC)
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|
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Tubugi-1-NPY
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[K4(C-βA-),F7,L17,P34]-hNPY
|
Neuropeptide Y receptor type 1 (NPY1R)
|
Tubugis
|
Disulfide bond
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(123B9)2L2PTX
|
123B9
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Ephrin type-A receptor 2 (EPHA2)
|
Paclitaxel
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Antitriazole
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|
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ANG-PTX
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Angiopep-2
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Prolow-density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 2 (LRP1; LRP2)
|
Paclitaxel
|
Ester bond
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|
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GnRH-III-[2ΔHis-3D-Tic, 8Lys(glutaryl-diamine-PTX)] conjugate
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GnRH-III
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Gonadotropin-releasing hormone receptor (GNRHR)
|
Paclitaxel
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Glutaric acid
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|
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GnRH-III-[2ΔHis-3D-Tic, 8Lys(glutaryl-Val-Ala-PABC-diamine-PTX)] conjugate
|
GnRH-III
|
Gonadotropin-releasing hormone receptor (GNRHR)
|
Paclitaxel
|
Val-Cit
|
|
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GnRH-III-[2ΔHis-3D-Tic,8Lys(glutaryl-Dau)] conjugate
|
GnRH-III
|
Gonadotropin-releasing hormone receptor (GNRHR)
|
Paclitaxel
|
Val-Ala
|
|
|
GnRH-III-[2His-3Trp,8Lys(glutaryl-Dau)] conjugate
|
GnRH-III
|
Gonadotropin-releasing hormone receptor (GNRHR)
|
Paclitaxel
|
Val-Ala
|
|
|
GnRH-III-[2His-3Trp,8Lys(glutaryl-diamine-PTX)] conjugate
|
GnRH-III
|
Gonadotropin-releasing hormone receptor (GNRHR)
|
Paclitaxel
|
Glutaric acid
|
|
|
CTVALPGGYVRVCVXVX - Paclitaxel conjugate
|
CTVALPGGYVRVCVXVX
|
Undisclosed
|
Paclitaxel
|
Benzyl
|
|
|
XYQWAVGHLM - Paclitaxel conjugate
|
XYQWAVGHLM
|
Undisclosed
|
Paclitaxel
|
Succinic Acid
|
|
|
EYQWAVGHLM - Paclitaxel conjugate
|
EYQWAVGHLM
|
Undisclosed
|
Paclitaxel
|
Succinic Acid
|
|
|
Lytic peptides 5 - Paclitaxel conjugate
|
Lytic peptides 5
|
Undisclosed
|
Paclitaxel
|
4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
|
|
|
FA-P3-PTX
|
Lytic peptides 5
|
Undisclosed
|
Paclitaxel
|
4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
|
|
|
Lytic peptides 6 - Paclitaxel conjugate
|
Lytic peptides 6
|
Undisclosed
|
Paclitaxel
|
4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
|
|
|
FA-P7-PTX
|
Lytic peptides 6
|
Undisclosed
|
Paclitaxel
|
4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
|
|
|
Penetratin - Paclitaxel conjugate 1
|
Penetratin
|
Undisclosed
|
Paclitaxel
|
Maleimide
|
|
|
Penetratin - Paclitaxel conjugate 2
|
Penetratin
|
Undisclosed
|
Paclitaxel
|
Maleimide
|
|
|
Penetratin fragment - Paclitaxel conjugate
|
Penetratin fragment
|
Undisclosed
|
Paclitaxel
|
Maleimide
|
|
|
BPP-PTX
|
BPP
|
Undisclosed
|
Paclitaxel
|
Succinic Acid
|
|
|
LLC2B-Mal-DM1
|
LLC2B
|
Undisclosed
|
Mertansine DM1
|
Thiol group (SH) and maleimide
|
|
|
LLC2B-SS-DM1
|
LLC2B
|
Undisclosed
|
Mertansine DM1
|
3-Disulfanylpropanoic Acid
|
|
|
cCPP-CBT
|
CWRWRKWRWR
|
Undisclosed
|
Cabazitaxel
|
Glutaric acid
|
|
|
TP1-cCPP-CBT
|
TP1-cCPP
|
Undisclosed
|
Cabazitaxel
|
Glutaric acid
|
|
|
TP2-cCPP-CBT
|
TP2-cCPP
|
Undisclosed
|
Cabazitaxel
|
Glutaric acid
|
|
|
SynB3PVGLIGPTX
|
SynB3
|
Undisclosed
|
Paclitaxel
|
PVGLIG
|
|
|
LTP-1
|
TTP-CPP
|
Undisclosed
|
Paclitaxel
|
Disulfide bond
|
|
|
NT4-CA4 ester
|
Branched neurotensin (NT4)
|
Undisclosed
|
Combretastatin A4
|
Ester bond
|
|
|
NT4-CA4 ether
|
Branched neurotensin (NT4)
|
Undisclosed
|
Combretastatin A4
|
Ether bond
|
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cyclo[DKP-isoDGR]-PEG4-GPLG-PABC-MMAE
|
cyclo[DKP-isoDGR]
|
Integrin alpha-V (ITGAV)
|
Monomethyl auristatin E
|
PEG4-GPLG-PABC
|