Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00063
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| PDC Name |
ANG-PTX
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| PDC Status |
Investigative
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| Indication |
In total 1 Indication(s)
Central nervous system disease
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| Structure |
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| Peptide Name |
Angiopep-2
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Peptide Info | ||||
| Receptor Name |
Prolow-density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 2 (LRP1; LRP2)
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Receptor Info | ||||
| Drug Name |
Paclitaxel
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Drug Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Ester bond
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Linker Info | ||||
| Formula |
C161H212N32O47S
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight | 3379.711 | ||||
| Lipid-water partition coefficient (xlogp) | -6.7264 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 39 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 51 | |||||
| Rotatable Bond Count (rotbonds) | 101 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Central nervous system disease | ||||
| Efficacy Data | Inhinition rate |
33.21 ± 3.32%
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| Administration Time | 24 h | ||||
| In Vitro Model | Glioblastoma | U87 cell | CVCL_3429 | ||
| Experiment 2 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Central nervous system disease | ||||
| Efficacy Data | Inhinition rate |
50.24 ± 4.75%
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| Administration Time | 48 h | ||||
| In Vitro Model | Glioblastoma | U87 cell | CVCL_3429 | ||
References