Receptor Information

General Information of This Receptor
Receptor ID
REC00011
Receptor Name
Intercellular adhesion molecule 1 (ICAM1)
Gene Name
ICAM1
Gene ID
3383
Synonym
Major group rhinovirus receptor; CD_antigen=CD54
Sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

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3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Family
the immunoglobulin superfamily. ICAM family
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins; (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T- lymphocytes and NK cell.

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Uniprot Entry
ICAM1_HUMAN
HGNC ID
HGNC:5344
KEGG ID
hsa:3383
Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
PDC Info PDC Name Drug Target Linker
 PDC Info 
MTX-cLABL
Methotrexate
Reduced folate transporter (SLC19A1)
Glu -carboxylic acid
PDC Info PDC Name Drug Target Linker
 PDC Info 
MTX-cLBEL
Methotrexate
Reduced folate transporter (SLC19A1)
Glu -carboxylic acid