Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00044
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| PDC Name |
68Ga-PSMA-617
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| Synonyms |
68Ga-Psma-617; PSMA-617 Ga-68; 7P5C02S4X8; UNII-7P5C02S4X8; 2247839-19-4; Gallate(3-)-68Ga, (N6-(N-((trans-4-(((2-(4,7,10-tris((carboxy-kappaO)methyl)-1,4,7,10-tetraazacyclododec-1-yl-kappaN1,kappaN4,kappaN7,kn10)acetyl-kappaO)amino)methyl)cyclohexyl)carbonyl)-3-(2-naphthalenyl)-L-alanyl)-N2-((((1S)-1,3-dicarboxyprop; Vipivotide tetraxetan gallium ga-68; GALLATE(3-)-68GA, (N6-(N-((TRANS-4-(((2-(4,7,10-TRIS((CARBOXY-.KAPPA.O)METHYL)-1,4,7,10-TETRAAZACYCLODODEC-1-YL-.KAPPA.N1,.KAPPA.N4,.KAPPA.N7,KN10)ACETYL-.KAPPA.O)AMINO)METHYL)CYCLOHEXYL)CARBONYL)-3-(2-NAPHTHALENYL)-L-ALANYL)-N2-((((1S)-1,3-DICARBOXYPROPYL)AMINO)CARBONYL)-L-LYSINATO(6-))-, HYDROGEN (1:3)
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| PDC Status |
Phase 2/3
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| Structure |
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| Peptide Name |
PSMA-617
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Peptide Info | ||||
| Receptor Name |
Glutamate carboxypeptidase 2 (FOLH1)
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Receptor Info | ||||
| Drug Name |
Gallium-68
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Drug Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
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Linker Info | ||||
| Peptide Modified Type |
The modification of binding with chemical molecules
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| Modified Segment |
Urea
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| ChEBI ID | ||||||
| Formula |
C49H68GaN9O16
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| #Ro5 Violations (Lipinski): 4 | Molecular Weight (mw) | 1107 | ||||
| Lipid-water partition coefficient (xlogp) | Not Available | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 8 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 20 | |||||
| Rotatable Bond Count (rotbonds) | 24 | |||||