Receptor Information
General Information of This Receptor
| Receptor ID |
REC00042
|
|||||
|---|---|---|---|---|---|---|
| Receptor Name |
Glutamate carboxypeptidase 2 (FOLH1)
|
|||||
| Gene Name |
FOLH1
|
|||||
| Gene ID | ||||||
| Synonym |
Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
|
|||||
| Sequence |
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
Click to Show/Hide
|
|||||
| 3D Structure | ||||||
| Family |
the peptidase M28 family. M28B subfamily
|
|||||
| Function |
Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Click to Show/Hide
|
|||||
| Uniprot Entry | ||||||
| HGNC ID | ||||||
| KEGG ID | ||||||
Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
PSMA-617
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
177Lu-PSMA-617
|
Lutetium-177
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
68Ga-PSMA-11
|
Gallium-68
|
Human Deoxyribonucleic acid (hDNA)
|
Aminocaproic acid
|
|
|
18F vipivotide traxetan
|
Fluorine-18
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
68Ga-PSMA-617
|
Gallium-68
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
225Ac-PSMA-617
|
Actinium-225
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
([α,β-3H]Nal)Lu-PSMA-617
|
Lutetium-175
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
[177Lu]Lu-4
|
Lutetium-177
|
Human Deoxyribonucleic acid (hDNA)
|
rac-(R)-2-(2-aminoacetamido)-3-(4-(2-(((R)-1-carboxy-2-phenylethyl)amino)-2-oxoethoxy)phenyl)propanoic acid
|
|
|
[177Lu]Lu-7
|
Lutetium-177
|
Human Deoxyribonucleic acid (hDNA)
|
rac-(R)-2-(2-aminoacetamido)-3-(4-(2-(((R)-1-carboxy-2-phenylethyl)amino)-2-oxoethoxy)phenyl)propanoic acid
|
|
|
[177Lu]Lu-P17-079
|
Lutetium-177
|
Human Deoxyribonucleic acid (hDNA)
|
Phosphonic Acid Linker
|
|
|
[177Lu]Lu-P17-081
|
Lutetium-177
|
Human Deoxyribonucleic acid (hDNA)
|
rac-(R)-2-(2-aminoacetamido)-3-(4-(2-(((R)-1-carboxy-2-phenylethyl)amino)-2-oxoethoxy)phenyl)propanoic acid
|
|
|
161Tb-PSMA-617
|
Terbium-161
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
175Lu-PSMA-617
|
Lutetium-175
|
Human Deoxyribonucleic acid (hDNA)
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
18F-PSMA-1007
|
Fluorine-18
|
Human Deoxyribonucleic acid (hDNA)
|
2-(4-(aminomethyl)benzamido)-3-(naphthalen-2-yl)propanoic acid
|
|
|
68Ga-PSMA HBED-CC
|
Gallium-68
|
Human Deoxyribonucleic acid (hDNA)
|
Aminocaproic acid
|
|
|
Piflufolastat F-18
|
Fluorine-18
|
Human Deoxyribonucleic acid (hDNA)
|
Amide bond
|
|
|
159Tb-PSMA-617
|
Terbium-159
|
Undisclosed
|
(S)-2-(4-(aminomethyl)cyclohexane-1-carboxamido)-3-(naphthalen-2-yl)propanoic acid
|
PSMA I&T
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
177Lu-PSMA I&T
|
Lutetium-177
|
Human Deoxyribonucleic acid (hDNA)
|
PSMA-I&T Linker
|
LDC10B
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
CBP-1018
|
Monomethyl auristatin E
|
Microtubule (MT)
|
Mc-Val-Cit-PAB-OH
|
PSMA-specific peptide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
Mipsagargin
|
12Adt-asp
|
Calcium-transporting ATPase type 2C member 1 (ATP2C1)
|
Amide bond
|