Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00311
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| PDC Name |
pHLIP-SS-DOX
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| PDC Status |
Investigative
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| Indication |
In total 1 Indication(s)
Breast cancer
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| Structure |
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| Peptide Name |
pHLIP (AEQ)
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Peptide Info | ||||
| Receptor Name |
DNA topoisomerase 2-alpha (TOP2A)
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Receptor Info | ||||
| Drug Name |
Doxorubicin
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Drug Info | ||||
| Therapeutic Target |
DNA topoisomerase 2-alpha (TOP2A)
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Target Info | ||||
| Linker Name |
Disulfide bond
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Linker Info | ||||
| Formula |
C223H319N45O69S2
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight | 4798.385 | ||||
| Lipid-water partition coefficient (xlogp) | -8.2068 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 59 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 66 | |||||
| Rotatable Bond Count (rotbonds) | 144 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 400 µM | |||
| In Vitro Model | Invasive breast carcinoma | MCF-7 cell | CVCL_0031 | ||
References