Target Information
General Information of This Target
| Target ID |
TAR10009
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| Target Name |
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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| Gene Name |
RRM2
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| Gene ID | ||||||
| Synonym |
RR2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit
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| Sequence |
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN FFEKRVGEYQRMGVMSSPTENSFTLDADF
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| 3D Structure | ||||||
| Family |
the ribonucleoside diphosphate reductase small chain family
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| Function |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
| KEGG ID | ||||||
Full List of The PDC Related to This Target
Investigative
| PDC Info | PDC Name | Peptide | Receptor | Drug | Linker |
|---|---|---|---|---|---|
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EETI-2.5Z-amide -gemcitabine
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EETI-2.5Z
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Integrin
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Gemcitabine
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Alkyne-Triazole
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EETI-2.5Z-carbamate -gemcitabine
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EETI-2.5Z
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Integrin
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Gemcitabine
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(3-(1H-1,2,3-triazol-4-yl)propyl)carbamic acid
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EETI-2.5Z-ester-gemcitabine
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EETI-2.5Z
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Integrin
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Gemcitabine
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3-(1H-1,2,3-Triazol-4-yl)propanoic acid
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EETI-2.5Z-Val-Ala-PAB-gemcitabine
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EETI-2.5Z
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Integrin
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Gemcitabine
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rac-4-((R)-2-((R)-2-(3-(1H-1,2,3-triazol-4-yl)propanamido)-3-methylbutanamido)propanamido)benzyl hydrogen carbonate
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D-Lys6-GnRH-gemcitabine(2G1)
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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Carbamic acid
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D-Lys6-GnRH-gemcitabine(2G2)
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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Carbamic acid
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D-Lys6-GnRH-gemcitabine(GSHG)
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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GSHG
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GOXG1
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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Boc-aminooxy acetic acid
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GOXG2
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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Boc-aminooxy acetic acid
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GN4OXG
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[D-Lys6]-LH-RH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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Boc-aminooxy acetic acid
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OGF-Gem
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OGF
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Opioid growth factor receptor (OGFR)
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Gemcitabine
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Succinic Acid
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[D-Lys6]-GnRH gemcitabine conjugate
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[D-Lys6]-GnRH
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Gonadotropin-releasing hormone receptor (GNRHR)
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Gemcitabine
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Glutaric acid
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