Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00146
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| PDC Name |
EETI-2.5Z-amide -gemcitabine
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| PDC Status |
Investigative
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| Indication |
In total 1 Indication(s)
Glioblastoma
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| Structure |
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| Peptide Name |
EETI-2.5Z
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Peptide Info | ||||
| Receptor Name |
Integrin
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Receptor Info | ||||
| Drug Name |
Gemcitabine
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Drug Info | ||||
| Therapeutic Target |
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Target Info | ||||
| Linker Name |
Alkyne-Triazole
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Linker Info | ||||
| Peptide Modified Type |
Amino acid modifications; Cyclization modification
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| Modified Segment |
Cyclization modification
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| Formula |
C148H220F2N48O50S6
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight | 3702.072 | ||||
| Lipid-water partition coefficient (xlogp) | -20.1763 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 44 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 60 | |||||
| Rotatable Bond Count (rotbonds) | 46 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
8.9 ± 1.2 nM
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| Evaluation Method | CCK-8 assay | ||||
| Description |
Cell proliferation was quantified 4 d after treatment with each compoundusing CCK-8 colorimetric assays and compared to the untreated control.
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| In Vitro Model | Glioblastoma | U-87MG cell | CVCL_0022 | ||
| Experiment 2 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Glioblastoma | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
2.8 ± 0.2 nM
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| Evaluation Method | CCK-8 assay | ||||
| Description |
Cell proliferation was quantified 4 d after treatment with each compoundusing CCK-8 colorimetric assays and compared to the untreated control.
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| In Vitro Model | Glioblastoma | U-87MG cell | CVCL_0022 | ||
References