Receptor Information
General Information of This Receptor
| Receptor ID |
REC00005
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| Receptor Name |
Pro-epidermal growth factor (EGF)
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| Gene Name |
EGF
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| Gene ID | ||||||
| Sequence |
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID
TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS EGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP HQMELTQ
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| 3D Structure | ||||||
| Function |
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro .
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
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Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
D4
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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DauQ=AoaGFLGD4G5HbPG
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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GFLG
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DauQ=AoaGFLGD4G5PEG
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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GFLG
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DauQ=AoaGFLGD4HbPG
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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GFLG
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DauQ=AoaGFLGD4PEG
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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GFLG
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Gefitinib LARLLT conjugate a
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Gefitinib
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Epidermal growth factor receptor (EGFR)
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Succinic Acid
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Gefitinib LARLLT conjugate b
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Gefitinib
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Epidermal growth factor receptor (EGFR)
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Glutaric acid
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Gefitinib LARLLT conjugate c
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Gefitinib
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Epidermal growth factor receptor (EGFR)
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Adipic acid
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Gefitinib LARLLT conjugate d
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Gefitinib
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Epidermal growth factor receptor (EGFR)
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Pimelic acid
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Gefitinib LARLLT conjugate e
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Gefitinib
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Epidermal growth factor receptor (EGFR)
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Suberic acid
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GE11
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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DauQ=AoaGFLGGE11G5HbPG
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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GFLG
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DauQ=AoaGFLGGE11G5PEG
|
Daunorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
GFLG
|
|
|
DauQ=AoaGFLGGE11HbPG
|
Daunorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
GFLG
|
|
|
DauQ=AoaGFLGGE11PEG
|
Daunorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
GFLG
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