Receptor Information
General Information of This Receptor
| Receptor ID |
REC00010
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| Receptor Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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| Gene Name |
ERBB2
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| Gene ID | ||||||
| Synonym |
HER2; MLN19; NEU; NGL; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen=CD340
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| Sequence |
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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| 3D Structure | ||||||
| Family |
the protein kinase superfamily, Tyr protein kinase family
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| Function |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
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| Uniprot Entry | ||||||
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Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
AHNP
| PDC Info | PDC Name | Drug | Target | Linker |
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MAHNP-Dox conjugate
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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HER2-targeting peptide P1
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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PDC-Z1
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Aminocaproic acid
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PDC-Z10
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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b-Thiosuccinimide
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PDC-Z11
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z12
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z2
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z3
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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GFLG
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PDC-Z4
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z5
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z6
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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b-Thiosuccinimide
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PDC-Z7
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z8
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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Disulfide bond
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PDC-Z9
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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b-Thiosuccinimide
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LNCaP-specific peptide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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KYL-TGX
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TGX-D1
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Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)
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PSA-cleavable linker (SSKYQSL)
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P1GCGCGT1
| PDC Info | PDC Name | Drug | Target | Linker |
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I-4 (NPNWGRSWYNQRFKGC=(-SS-O-COO-CPT)GC=(-SS-O-COO-CPT)GRIKPRKGYTR)
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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2-(Disulfanyl)ethyl hydrogen carbonate
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I-5 (NPNWGRSWYNQRFKGC=(-SS-COO-CPT)GC=(-SS-COO-CPT)GRIKPRKGYTR)
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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3-Disulfanylpropanoic Acid
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I-6 (NPNWGRSWYNQRFKGC=(-S-Maleimide-CPT)GC=(-S-Maleimide-CPT)GRIKPRKGYTR)
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
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P1GCGT1
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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I-1 (NPNWGRSWYNQRFKGC=(-SS-O-COO-CPT)GRIKPRKGYTR)
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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2-(Disulfanyl)ethyl hydrogen carbonate
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I-2 (NPNWGRSWYNQRFKGC=(-SS-COO-CPT)GRIKPRKGYTR)
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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3-Disulfanylpropanoic Acid
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I-3 (NPNWGRSWYNQRFKGC=(-S-Maleimide-CPT)GRIKPRKGYTR)
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
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rL-A9
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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rL-A9-DOX
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Sulfo-SMCC
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RNWELRLK
| PDC Info | PDC Name | Drug | Target | Linker |
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DOXO-EMCH-(RNWELRLK-PEG4)2
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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EMCH
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SMAC-P1 S1
| PDC Info | PDC Name | Drug | Target | Linker |
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SMAC-P1 CPT conjugates 1
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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2-(Disulfanyl)ethyl hydrogen carbonate
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SMAC-P1 CPT conjugates 2
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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3-Disulfanylpropanoic Acid
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SMAC-P1 CPT conjugates 3
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
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SMAC-P1 S2
| PDC Info | PDC Name | Drug | Target | Linker |
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SMAC-P1 CPT conjugates 4
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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2-(Disulfanyl)ethyl hydrogen carbonate
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SMAC-P1 CPT conjugates 5
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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3-Disulfanylpropanoic Acid
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SMAC-P1 CPT conjugates 6
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
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SMAC-P1 S3
| PDC Info | PDC Name | Drug | Target | Linker |
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SMAC-P1 CPT conjugates 7
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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2-(Disulfanyl)ethyl hydrogen carbonate
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SMAC-P1 CPT conjugates 8
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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3-Disulfanylpropanoic Acid
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SMAC-P1 CPT conjugates 9
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Camptothecin
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DNA topoisomerase 1 (TOP1)
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4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
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