Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00038
|
|||||
|---|---|---|---|---|---|---|
| PDC Name |
68Ga-DOTANOC
|
|||||
| Synonyms |
68-Ga-Dotanoc; (68Ga)-Dotanoc; DOTA-NOC Ga-68; 8AHG0Z4Z5M; DOTA-nal3-octreotide Ga-68; UNII-8AHG0Z4Z5M; 1040397-47-4; 68GA-DOTANOC; GALLIUM-68 DOTANOC; DOTANOC GALLIUM GA-68
Click to Show/Hide
|
|||||
| PDC Status |
Phase 1
|
|||||
| Indication |
In total 1 Indication(s)
Neuroendocrine tumour
|
|||||
| Structure |
|
|||||
| Peptide Name |
3-Nal-Octreotide
|
Peptide Info | ||||
| Receptor Name |
Somatostatin receptor type 1 (SSTR1)
|
Receptor Info | ||||
| Drug Name |
Gallium-68
|
Drug Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
|
Target Info | ||||
| Linker Name |
Amide bond
|
Linker Info | ||||
| Peptide Modified Type |
Amino acid modifications; Cyclization modification
|
|||||
| Modified Segment |
D-amino acids
|
|||||
| Ternimal Modification |
N-terminal modification
|
|||||
| Drugbank ID | ||||||
| Formula |
C69H91GaN14O17S2
|
|||||
| #Ro5 Violations (Lipinski): 4 | Molecular Weight (mw) | 1520.6 | ||||
| Lipid-water partition coefficient (xlogp) | Not Available | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 13 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 24 | |||||
| Rotatable Bond Count (rotbonds) | 23 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Neuroendocrine tumour | ||||
| Efficacy Data | Difference in detection ratio |
27.50%
|
|||
| Patients Enrolled |
75 patients with histologically confirmed neuroendocrine tumours and routine clinical.
|
||||
| MOA of PDC |
18F-AlF-OC is noninferior and even superior to 68Ga-DOTATATE/NOC PET in NET patients. This validates 18F-AlF-OC as an option for clinical practice somatostatin receptor PET.
|
||||
| Description |
The resulting mean DDR was 15.8%, with a lower margin of the 95% CI (95% CI, 9.6%-22.0%) higher than -15%, which is the prespecified boundary for noninferiority. The mean DDRs for the 68Ga-DOTATATE and 68Ga-DOTANOC subgroups were 11.8% (95% CI, 4.3-19.3) and 27.5% (95% CI, 17.8-37.1), respectively.
|
||||
References