Receptor Information
General Information of This Receptor
| Receptor ID |
REC00031
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| Receptor Name |
Somatostatin receptor type 1 (SSTR1)
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| Gene Name |
SSTR1
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| Gene ID | ||||||
| Synonym |
SRIF-2
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| Sequence |
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAIL
ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL RHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAIC LCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQD DATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKS RAYSVEDFQPENLESGGVFRNGTCTSRITTL
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| 3D Structure | ||||||
| Family |
the G-protein coupled receptor 1 family
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| Function |
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
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| Uniprot Entry | ||||||
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Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
3-Tyr-Octreotate
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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177Lu-DOTATATE
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Lutetium-177
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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68Ga-DOTATATE
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Gallium-68
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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Copper dotatate Cu-64
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Copper-64
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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TATE-SS-Ama
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Amatoxins
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Undisclosed
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Disulfide bond
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TATE-VCit-Ama
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Amatoxins
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Undisclosed
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Val-Cit
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TATE-PEG-Ama
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Amatoxins
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Undisclosed
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PEG8
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BBB1-Lys(BBB1)-(sarcosine)3-TATE
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Ortho carborane
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Undisclosed
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(Sarcosine)3
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Octreotide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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111In-DTPA-octreotide
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Indium-111
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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Octreotide doxorubicin conjugate
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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[18F]AlF-NOTA-octreotide
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Fluorine-18
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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99mTc-octreotide
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Technetium-99m
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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Edotreotide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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90Y-DOTATOC
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Yttrium-90
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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225Ac-DOTATOC
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Actinium-225
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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Edotreotide - DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivative conjugate 1
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DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivative
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Undisclosed
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Triazole
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Edotreotide - 3-(2-propyn-1-yloxy)-, S-[(2,4,6-trimethoxyphenyl)methyl] benzenecarbothioic acid ester conjugate
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3-(2-propyn-1-yloxy)-, S-[(2,4,6-trimethoxyphenyl)methyl] benzenecarbothioic acid ester
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Undisclosed
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Triazole
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Edotreotide - DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivative conjugate
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DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivative
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Undisclosed
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Triazole
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Edotreotide - 3,5-bis(2-propyn-1-yloxy)-, S-[(2,4,6-trimethoxyphenyl)methyl] benzenecarbothioic acid ester conjugate
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3,5-bis(2-propyn-1-yloxy)-, S-[(2,4,6-trimethoxyphenyl)methyl] benzenecarbothioic acid ester
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Undisclosed
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Triazole
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3-Nal-Octreotide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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68Ga-DOTANOC
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Gallium-68
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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3-Tyr-Octreotide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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67Ga-MMC(TMZ)-TOC
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Temozolomide
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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MMC(TMZ)-TOC
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Temozolomide
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Human Deoxyribonucleic acid (hDNA)
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Amide bond
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