Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00267
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| PDC Name |
PDC-5a
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| PDC Status |
Investigative
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| Indication |
In total 1 Indication(s)
Breast cancer
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| Structure |
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| Peptide Name |
[K4,F7,K22,P34]-NPY
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Peptide Info | ||||
| Receptor Name |
Neuropeptide Y receptor type 1 (NPY1R)
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Receptor Info | ||||
| Drug Name |
Methotrexate
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Drug Info | ||||
| Therapeutic Target |
Reduced folate transporter (SLC19A1)
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Target Info | ||||
| Linker Name |
Amide bond
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Linker Info | ||||
| Formula |
C218H315N61O59
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| #Ro5 Violations (Lipinski): 5 | Molecular Weight | 4734.286 | ||||
| Lipid-water partition coefficient (xlogp) | -13.15133 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 61 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 65 | |||||
| Rotatable Bond Count (rotbonds) | 149 | |||||
Full List of Activity Data of This Peptide-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
2.9 (8.5 ± 0.1) nM
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| In Vitro Model | Normal | COS-7 cell | CVCL_0224 | ||
| Experiment 2 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
209 (6.7 ± 0.1) nM
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| In Vitro Model | Normal | COS-7 cell | CVCL_0224 | ||
| Experiment 3 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
18 (4.8 ± 0.1) μM
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cell | CVCL_0419 | ||
| Experiment 4 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 25 µM | |||
| In Vitro Model | Invasive breast carcinoma | T-47D cell | CVCL_0553 | ||
| Experiment 5 Reporting the Activity Data of This PDC | [1] | ||||
| Indication | Breast cancer | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 25 µM | |||
| In Vitro Model | Breast adenocarcinoma | MDA-MB-231 cell | CVCL_0062 | ||
References