Peptide-drug Conjugate Information
General Information of This Peptide-drug Conjugate (PDC)
| PDC ID |
PDC_00304
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| PDC Name |
Peptide-Dox hydrazone
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| PDC Status |
Investigative
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| Indication |
In total 1 Indication(s)
Triple-negative breast cancer
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| Structure |
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| Peptide Name |
Peptide 18-4
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Peptide Info | ||||
| Receptor Name |
Keratin, type II cytoskeletal 1 (KRT1)
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Receptor Info | ||||
| Drug Name |
Doxorubicin
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Drug Info | ||||
| Therapeutic Target |
DNA topoisomerase 2-alpha (TOP2A)
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Target Info | ||||
| Linker Name |
(Z)-N'-(2-hydroxyethylidene)-6-(3-mercapto-2,5-dioxopyrrolidin-1-yl)hexanehydrazide
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Linker Info | ||||
| Formula |
C103H139N21O28S
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| #Ro5 Violations (Lipinski): 4 | Molecular Weight | 2151.431 | ||||
| Lipid-water partition coefficient (xlogp) | -1.19153 | |||||
| Hydrogen Bond Donor Count (hbonddonor) | 26 | |||||
| Hydrogen Bond Acceptor Count (hbondacc) | 32 | |||||
| Rotatable Bond Count (rotbonds) | 57 | |||||