Receptor Information
General Information of This Receptor
| Receptor ID |
REC00009
|
|||||
|---|---|---|---|---|---|---|
| Receptor Name |
Keratin, type II cytoskeletal 1 (KRT1)
|
|||||
| Gene Name |
KRT1
|
|||||
| Gene ID | ||||||
| Synonym |
KRTA; 67 kDa cytokeratin; Cytokeratin-1; Hair alpha protein; Keratin-1; Type-II keratin Kb1
|
|||||
| Sequence |
MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGG
GFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFG GFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSRE REQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRR RVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVD LQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYED IAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQIS NLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIA TYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYG SGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSG GRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR
Click to Show/Hide
|
|||||
| 3D Structure | ||||||
| Family |
the intermediate filament family
|
|||||
| Function |
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Click to Show/Hide
|
|||||
| Uniprot Entry | ||||||
| HGNC ID | ||||||
| KEGG ID | ||||||
Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
Peptide 18-4
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
Peptide 18-4-doxorubicin
|
Doxorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
Sulfo-SMCC
|
|
|
Peptide-Dox hydrazone
|
Doxorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
(Z)-N'-(2-hydroxyethylidene)-6-(3-mercapto-2,5-dioxopyrrolidin-1-yl)hexanehydrazide
|
|
|
Peptide 18-4 doxorubicin conjugate 1
|
Doxorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
Glutaric acid
|
|
|
Peptide 18-4 doxorubicin conjugate 2
|
Doxorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
Glutaric acid
|
|
|
POSS-p18-4-Ce6(PPC)
|
Chlorin e6
|
Undisclosed
|
POSS
|
Peptide 18-4 analog
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
Peptide 18-4 analog doxorubicin conjugate
|
Doxorubicin
|
DNA topoisomerase 2-alpha (TOP2A)
|
4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
|
WX(D)EAAYQK(D)FL peptide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
FITC-WX(D)EAAYQK(D)FL peptide conjugate
|
Fluorescein isothiocyanate
|
Undisclosed
|
β-Alanine
|
WX(D)EAAYQKFL peptide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
FITC-WX(D)EAAYQKFL peptide conjugate
|
Fluorescein isothiocyanate
|
Undisclosed
|
β-Alanine
|
WXEAAYQK(D)FL cyclic peptide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
FITC-WXEAAYQK(D)FL cyclic peptide conjugate
|
Fluorescein isothiocyanate
|
Undisclosed
|
β-Alanine
|
WXEAAYQK(D)FL peptide
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
|
FITC-WXEAAYQK(D)FL peptide conjugate
|
Fluorescein isothiocyanate
|
Undisclosed
|
β-Alanine
|