Receptor Information
General Information of This Receptor
| Receptor ID |
REC00033
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| Receptor Name |
Gonadotropin-releasing hormone receptor (GNRHR)
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| Gene Name |
GNRHR
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| Gene ID | ||||||
| Synonym |
GRHR
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| Sequence |
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| 3D Structure | ||||||
| Family |
the G-protein coupled receptor 1 family
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| Function |
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
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| Uniprot Entry | ||||||
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Each Peptide-drug Conjuate AND It's Component Related to This Receptor
Full List of The PDC Related to This Receptor
GnRH analogs 1
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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[d-Cys6-des-Gly10-Pro9-NH2]-GnRH-Dox
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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N-succinimidyl-3-maleimidopropionate
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GnRH analogs 2
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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[d-Cys6-des-Gly10-Pro9-NHEt]-GnRH-Dox
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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N-succinimidyl-3-maleimidopropionate
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GnRH analogs 3
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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[d-Cys6-des-Gly10-Pro9-α-azaGly-NH2]-GnRH-Dox
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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N-succinimidyl-3-maleimidopropionate
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GnRH-III
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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[4Lys(Ac),8Lys(Dau=Aoa)]-GnRH-III
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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[4Lys(Dau=Aoa),8Lys(Dau=Aoa)]-GnRH-III
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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[8Lys(Dau=Aoa-GFLG)]-GnRH-III
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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[8Lys(Dau=Aoa-K(Dau=Aoa))]GnRH-III
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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[8Lys(Dau=Aoa-LRRY)]-GnRH-III
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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[8Lys(Dox-O-glut)]-GnRH-III
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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GnRH-III-[2ΔHis, 3D-Tic, 4Lys(Bu), 7D-Trp 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[2ΔHis, 3D-Tic, 4Lys(Bu), 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[2ΔHis, 3D-Tic, 7D-Trp 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[2ΔHis, 3D-Tic, 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[2ΔHis-3D-Tic, 8Lys(glutaryl-Val-Ala-PABC-Dau conjugate
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Val-Ala
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GnRH-III-[2ΔHis-3D-Tic, 8Lys(glutaryl-diamine-PTX)] conjugate
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Paclitaxel
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Microtubule (MT)
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Glutaric acid
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GnRH-III-[2ΔHis-3D-Tic,8Lys(glutaryl-Val-Cit-PABC-Dau)] conjugate
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Val-Cit
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GnRH-III-[2ΔHis-3D-Tic,8Lys(glutaryl-Val-Cit-PABC-diamine-PTX)] conjugate
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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GnRH-III-[2His-3Trp,8Lys(glutaryl-Val-Ala-PABC-Dau)] conjugate
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Val-Ala
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GnRH-III-[2His-3Trp,8Lys(glutaryl-Val-Cit-PABC-Dau)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Val-Cit
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GnRH-III-[2His-3Trp,8Lys(glutaryl-Val-Cit-PABC-diamine-PTX)] conjugate
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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GnRH-III-[3D-Tic, 4Lys(Bu), 7D-Trp 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[3D-Tic, 4Lys(Bu), 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[3D-Tic, 7D-Trp 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[3D-Tic, 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[3D-Trp, 4Lys(Bu), 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[3D-Trp, 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[4Lys(Bu), 6Asp(OMe), 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[4Lys(Bu), 8Lys(Dau=Aoa), 10ΔGly-NH-Et]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[4Lys(Bu), 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[6Asp(OMe), 8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[8Lys(Dau=Aoa), 10ΔGly-NH-Et]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[8Lys(Dau=Aoa)]
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Daunorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Aminooxyacetic acid
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GnRH-III-[2ΔHis-3D-Tic, 8Lys(glutaryl-Val-Ala-PABC-diamine-PTX)] conjugate
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Paclitaxel
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Microtubule (MT)
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Val-Cit
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GnRH-III-[2ΔHis-3D-Tic,8Lys(glutaryl-Dau)] conjugate
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Paclitaxel
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Microtubule (MT)
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Val-Ala
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GnRH-III-[2His-3Trp,8Lys(glutaryl-Dau)] conjugate
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Paclitaxel
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Microtubule (MT)
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Val-Ala
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GnRH-III-[2His-3Trp,8Lys(glutaryl-diamine-PTX)] conjugate
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Paclitaxel
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Microtubule (MT)
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Glutaric acid
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[D-Lys6]-LH-RH
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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[D-Lys6]-LH-RH - Doxorubicin conjugate
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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XHWSYKLRPG - Doxorubicin conjugate
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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XHWSYKLRPG - Protoporphyrin IX conjugate
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Protoporphyrin IX
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Hematopoietic prostaglandin D synthase (HPGDS)
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Undisclosed
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D-Lys6-GnRH-gemcitabine(2G1)
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Carbamic acid
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D-Lys6-GnRH-gemcitabine(2G2)
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Carbamic acid
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D-Lys6-GnRH-gemcitabine(GSHG)
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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GSHG
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GOXG1
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Boc-aminooxy acetic acid
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GOXG2
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Boc-aminooxy acetic acid
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GN4OXG
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Boc-aminooxy acetic acid
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AEZS-108
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Doxorubicin
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DNA topoisomerase 2-alpha (TOP2A)
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Glutaric acid
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[D-Lys6]-GnRH
| PDC Info | PDC Name | Drug | Target | Linker |
|---|---|---|---|---|
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[D-Lys6]-GnRH gemcitabine conjugate
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Gemcitabine
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Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
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Glutaric acid
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